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11.
AbstractWith the rapid progress of information technologies, cars have been made increasingly intelligent. This allows cars to act as cognitive agents, i.e., to acquire knowledge and understanding of the driving habits and behavioral characteristics of drivers (i.e., driving behavioral fingerprint) through experience. Such knowledge can be then reused to facilitate the interaction between a car and its driver, and to develop better and safer car controls. In this paper, we propose a novel approach to extract the driver’s driving behavioral fingerprints based on our conceptual framework Experience-Oriented Intelligent Things (EOIT). EOIT is a learning system that has the potential to enable Internet of Cognitive Things (IoCT) where knowledge can be extracted from experience, stored, evolved, shared, and reused aiming for cognition and thus intelligent functionality of things. By catching driving data, this approach helps cars to collect the driver’s pedal and steering operations and store them as experience; eventually, it uses obtained experience for the driver’s driving behavioral fingerprint extraction. The initial experimental implementation is presented in the paper to demonstrate our idea, and the test results show that it outperforms the Deep Learning approaches (i.e., deep fully connected neural networks and recurrent neural networks/Long Short-Term Memory networks). 相似文献
12.
Daniel Boon Loong Teh Akshaya Bansal Chou Chai Tan Boon Toh Robert Alan Jappy Tucker Gil Gerald Lasam Gammad Yanzhuang Yeo Zhendong Lei Xiang Zheng Fengyuan Yang John S. Ho Nagarjun Bolem Bing Cheng Wu Muthu Kumar Gnanasammandhan Lissa Hooi Gavin Stewart Dawe Camilo Libedinsky Wei-Yi Ong Barry Halliwell Edward Kai-Hua Chow Kah-Leong Lim Yong Zhang Brian K. Kennedy 《Advanced materials (Deerfield Beach, Fla.)》2020,32(29):2001459
Near-infrared (NIR) activatable upconversion nanoparticles (UCNPs) enable wireless-based phototherapies by converting deep-tissue-penetrating NIR to visible light. UCNPs are therefore ideal as wireless transducers for photodynamic therapy (PDT) of deep-sited tumors. However, the retention of unsequestered UCNPs in tissue with minimal options for removal limits their clinical translation. To address this shortcoming, biocompatible UCNPs implants are developed to deliver upconversion photonic properties in a flexible, optical guide design. To enhance its translatability, the UCNPs implant is constructed with an FDA-approved poly(ethylene glycol) diacrylate (PEGDA) core clad with fluorinated ethylene propylene (FEP). The emission spectrum of the UCNPs implant can be tuned to overlap with the absorption spectra of the clinically relevant photosensitizer, 5-aminolevulinic acid (5-ALA). The UCNPs implant can wirelessly transmit upconverted visible light till 8 cm in length and in a bendable manner even when implanted underneath the skin or scalp. With this system, it is demonstrated that NIR-based chronic PDT is achievable in an untethered and noninvasive manner in a mouse xenograft glioblastoma multiforme (GBM) model. It is postulated that such encapsulated UCNPs implants represent a translational shift for wireless deep-tissue phototherapy by enabling sequestration of UCNPs without compromising wireless deep-tissue light delivery. 相似文献
13.
Pablo Hernndez‐Alonso Christopher Papandreou Mnica Bull Miguel Ruiz‐Canela Courtney Dennis Amy Deik Dong D. Wang Marta Guasch‐Ferr Edward Yu Estefanía Toledo Cristina Razquin Dolores Corella Ramon Estruch Emilio Ros Montserrat Fit Fernando Ars Miquel Fiol Lluís Serra‐Majem Liming Liang Clary B. Clish Miguel A Martínez‐Gonzlez Frank B Hu Jordi Salas‐Salvad 《Molecular nutrition & food research》2019,63(17)
14.
Meysam Heydari Gharahcheshmeh Maxwell T. Robinson Edward F. Gleason Karen K. Gleason 《Advanced functional materials》2021,31(14):2008712
Engineering the texture and nanostructure to improve the electrical conductivity of semicrystalline conjugated polymers must address the rate-limiting step for charge carrier transport. In highly face-on orientation, the charge transport between chains within a crystallite becomes rate-limiting, which is highly sensitive to the π–π stacking distance and interchain charge transfer integral. Here, face-on oriented semicrystalline poly(3,4-ethylenedioxythiophene) (PEDOT) thin films are grown via water-assisted (W-A) oxidative chemical vapor deposition (oCVD). Combining W-A with the volatile oxidant, antimony pentachloride, yields an optimized electrical conductivity of 7520 ± 240 S cm−1, a record for PEDOT thin films. Systematic control of π–π stacking distance from 3.50 Å down to 3.43 Å yields an electrical conductivity enhancement of ≈ 1140%. The highest electrical conductivity also corresponds to minimum in Urbach energy of 205 meV, indicating superior morphological order. The figure of merit for transparent conductors, σdc/σop, reaches a maximum value of 94, which is 1.9 × and 6.7 × higher than oCVD PEDOT grown without W-A and utilizing vanadium oxytrichloride and iron chloride oxidizing agents, respectively. The W-A oCVD is single-step all-dry process and provides conformal coverage, allowing direct growth on mechanical flexible, rough, and structured surfaces without the need for complex and costly transfer steps. 相似文献
15.
16.
Yan-Bo Zhang Xiulian Wang Edward A. Meister Ke-Rui Gong Shao-Chun Yan Guo-Wei Lu Xun-Ming Ji Guo Shao 《International journal of molecular sciences》2014,15(6):10999-11012
It is well known that cobalt chloride (CoCl2) can enhance the stability of hypoxia-inducible factor (HIF)-1α. The aim of this study is to detect the effect of CoCl2 on the hypoxia tolerance of mice which were repeatedly exposed to autoprogressive hypoxia. Balb/c mice were randomly divided into groups of chemical pretreatment and normal saline (NS), respectively injected with CoCl2 and NS 3 h before exposure to hypoxia for 0 run (H0), 1 run (H1), and 4 runs (H4). Western Blot, electrophoretic mobility shift assay (EMSA), extracellular recordings population spikes in area cornus ammonis
I (CA 1) of mouse hippocampal slices and real-time were used in this study. Our results demonstrated that the tolerance of mice to hypoxia, the changes of HIF-1α protein level and HIF-1 DNA binding activity in mice hippocampus, the mRNA level of erythropoietin (EPO) and vascular endothelial growth factor (VEGF), and the disappearance time of population spikes of hippocampal slices were substantially different between the control group and the CoCl2 group. Over-induction of HIF-1α by pretreatment with CoCl2 before hypoxia did not increase the hypoxia tolerance. 相似文献
17.
Binding Mode and Structure–Activity Relationships around Direct Inhibitors of the Nrf2–Keap1 Complex 下载免费PDF全文
Dr. Eric Jnoff Dr. Claudia Albrecht Dr. John J. Barker Dr. Oliver Barker Dr. Edward Beaumont Dr. Steven Bromidge Dr. Frederick Brookfield Dr. Mark Brooks Dr. Christian Bubert Dr. Tom Ceska Vincent Corden Dr. Graham Dawson Dr. Stephanie Duclos Dr. Tara Fryatt Dr. Christophe Genicot Dr. Emilie Jigorel Dr. Jason Kwong Rosemary Maghames Innocent Mushi Dr. Richard Pike Dr. Zara A. Sands Dr. Myron A. Smith Dr. Christopher C. Stimson Dr. Jean‐Philippe Courade 《ChemMedChem》2014,9(4):699-705
An X‐ray crystal structure of Kelch‐like ECH‐associated protein (Keap1) co‐crystallised with (1S,2R)‐2‐[(1S)‐1‐[(1,3‐dioxo‐2,3‐dihydro‐1H‐isoindol‐2‐yl)methyl]‐1,2,3,4‐tetrahydroisoquinolin‐2‐carbonyl]cyclohexane‐1‐carboxylic acid (compound (S,R,S)‐ 1 a ) was obtained. This X‐ray crystal structure provides breakthrough experimental evidence for the true binding mode of the hit compound (S,R,S)‐ 1 a , as the ligand orientation was found to differ from that of the initial docking model, which was available at the start of the project. Crystallographic elucidation of this binding mode helped to focus and drive the drug design process more effectively and efficiently. 相似文献
18.
Factory solvent seaming is the method and process whereby several rolls of material, varying in width from 60 to 76 in (1·52 to 1·93 m), and weight from 900 lb to 1200 lb (4· to 5·3 kN) each are joined (fabricated) under controlled factory conditions into large panels. 相似文献
19.
Edward A. Cook 《Landscape and urban planning》2002,58(2-4)
Analysis and planning of ecological networks is a relatively new phenomenon and is a response to fragmentation and deterioration of quality of natural systems. In urban areas, the problems of land use intransigence, political and jurisdictional issues create a difficult environment for implementing ecological networks. The specific questions addressed in this research program revolve around the viability of planning an ecological network in an urban landscape. The development and articulation of an ecological network plan was undertaken previously and in this paper, a series of assays of landscape structure are used to examine the viability of an ecological network in the Phoenix, Arizona urban area. Three principal analyses were utilized: (1) patch content analysis, (2) corridor content analysis, and (3) network structure analysis. Patch and corridor content analyses examined the internal characteristic and immediate context for each of the 89 ecological network elements. The network structure analysis incorporates a process for aggregating results of patch and corridor analyses and incorporates indicators that describe interrelationships between landscape elements. For each of these analyses the existing condition was compared to the optimal plan to demonstrate the level of change that can be expected. The results and conclusions of this research are that an ecological network plan provides modest but important improvement in ecological systems in the Phoenix urban area. 相似文献
20.
Urban landscape networks: an ecological planning framework 总被引:7,自引:0,他引:7
Edward A. Cook 《Landscape Research》1991,16(3):7-15
This paper presents a framework for the planning of urban landscape networks in an attempt to have nature areas integrated into traditional urban land-use planning. The biophysical and socio-economic benefits of such a network are discussed to provide justification for this incorporation. A framework is described, building upon ecological planning processes and incorporating theory and methodology from landscape ecology. The framework includes an assessment of natural and cultural resources, formulating the spatial structure of the network and examination of network components. Implementation strategies are discussed within the context of traditional urban land-use planning practice. 相似文献